Examination of the Lille Apathy Rating Scale in Parkinson disease
Identifieur interne : 002316 ( Main/Exploration ); précédent : 002315; suivant : 002317Examination of the Lille Apathy Rating Scale in Parkinson disease
Auteurs : Laura B. Zahodne [États-Unis] ; Shamar Young [États-Unis] ; Lindsey Kirsch-Darrow [États-Unis] ; Anne Nisenzon [États-Unis] ; Hubert H. Fernandez [États-Unis] ; Michael S. Okun [États-Unis] ; Dawn Bowers [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-04-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Affect (physiology), Aged, Aged, 80 and over, Analysis of Variance, Apathy, Depression (diagnosis), Depression (etiology), Evaluation scale, Female, Humans, Male, Middle Aged, Mood Disorders (diagnosis), Mood Disorders (etiology), Nervous system diseases, Parkinson Disease (complications), Parkinson Disease (psychology), Parkinson disease, Parkinson's disease, Psychiatric Status Rating Scales, ROC Curve, Reproducibility of Results, apathy, rating scales.
- MESH :
- complications : Parkinson Disease.
- diagnosis : Depression, Mood Disorders.
- etiology : Depression, Mood Disorders.
- physiology : Affect.
- psychology : Parkinson Disease.
- Adult, Aged, Aged, 80 and over, Analysis of Variance, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, ROC Curve, Reproducibility of Results.
Abstract
Apathy is a unique, multidimensional syndrome commonly encountered in patients with Parkinson disease (PD). Recently, the Lille Apathy Rating Scale (LARS), a semistructured interview yielding a global score, and composite subscores for different domains of apathy (i.e., cognitive, behavioral, affective, self awareness), was developed and given to a sample of patients with PD in France. This study is the first outside of its original developers to examine the English language version of the LARS in PD. We found the LARS to be a coherent instrument demonstrating both convergent and divergent validity, as compared to the Apathy Scale (AS) and Beck Depression Inventory (BDI‐II). Using a receiver operating characteristic (ROC) analysis comparing the LARS to the AS, a validated and widely‐used measure, we identified a cut‐off score (sensitivity = 64%, specificity = 92%, PPV = 88%, NPV = 75%) that was higher than that proposed by the original authors, who derived their cut‐off by comparing LARS global scores to clinical judgments of apathy. Although the present study does not compare the LARS to a diagnostic gold standard or promote its utility for diagnosing apathy, it provides further support for the LARS as a promising instrument to examine apathy in PD. © 2009 Movement Disorder Society
Url:
- https://api.istex.fr/document/8A9E71F8C2267E2ACFF3406DF478D5318D8B7D51/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045860
DOI: 10.1002/mds.22441
Affiliations:
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Le document en format XML
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Recently, the Lille Apathy Rating Scale (LARS), a semistructured interview yielding a global score, and composite subscores for different domains of apathy (i.e., cognitive, behavioral, affective, self awareness), was developed and given to a sample of patients with PD in France. This study is the first outside of its original developers to examine the English language version of the LARS in PD. We found the LARS to be a coherent instrument demonstrating both convergent and divergent validity, as compared to the Apathy Scale (AS) and Beck Depression Inventory (BDI‐II). Using a receiver operating characteristic (ROC) analysis comparing the LARS to the AS, a validated and widely‐used measure, we identified a cut‐off score (sensitivity = 64%, specificity = 92%, PPV = 88%, NPV = 75%) that was higher than that proposed by the original authors, who derived their cut‐off by comparing LARS global scores to clinical judgments of apathy. Although the present study does not compare the LARS to a diagnostic gold standard or promote its utility for diagnosing apathy, it provides further support for the LARS as a promising instrument to examine apathy in PD. © 2009 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Floride</li></region></list><tree><country name="États-Unis"><region name="Floride"><name sortKey="Zahodne, Laura B" sort="Zahodne, Laura B" uniqKey="Zahodne L" first="Laura B." last="Zahodne">Laura B. Zahodne</name></region><name sortKey="Bowers, Dawn" sort="Bowers, Dawn" uniqKey="Bowers D" first="Dawn" last="Bowers">Dawn Bowers</name><name sortKey="Fernandez, Hubert H" sort="Fernandez, Hubert H" uniqKey="Fernandez H" first="Hubert H." last="Fernandez">Hubert H. Fernandez</name><name sortKey="Kirsch Arrow, Lindsey" sort="Kirsch Arrow, Lindsey" uniqKey="Kirsch Arrow L" first="Lindsey" last="Kirsch-Darrow">Lindsey Kirsch-Darrow</name><name sortKey="Nisenzon, Anne" sort="Nisenzon, Anne" uniqKey="Nisenzon A" first="Anne" last="Nisenzon">Anne Nisenzon</name><name sortKey="Okun, Michael S" sort="Okun, Michael S" uniqKey="Okun M" first="Michael S." last="Okun">Michael S. Okun</name><name sortKey="Young, Shamar" sort="Young, Shamar" uniqKey="Young S" first="Shamar" last="Young">Shamar Young</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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